TBMT19 
Models in System Biology, 2 ECTS credits.
/Systembiologisk modellering/
For:
TB


Prel. scheduled
hours: 18
Rec. selfstudy hours: 35


Area of Education: Engineering
Main field of studies: Biotechnology


Advancement level
(G1, G2, A): G2


Aim:
This course will provide experience in mathematical modeling of biological systems. After completing this course, the participant shall be able to:
 explain why mathematical modeling is a tool in biological experimentation; explain some of the common mistakes
 construct a mathematical model of a class of biological systems
 analyzing, structuring and simulating mathematical models based on differential equations
 use methods for structured modeling in systems biology
 adapt mathematical models to measured data
 validate mathematical models to measured data; basic statistical tests
 use modern computerized tools for mathematical modeling in systems biology
 apply and integrate this with knowledge from previous courses


Prerequisites: (valid for students admitted to programmes within which the course is offered)
Basics courses in Chemistry, Biology and Mathematics
Note: Admission requirements for nonprogramme students usually also include admission requirements for the programme and threshhold requirements for progression within the programme, or corresponding.


Organisation:
The course consists of lectures and a large laboratory assignment and voluntary preassignments. The course is examined by two minor tests together with oral discussions of the laboratory work.
The course runs for the first three weeks during the spring semester.


Course contents:
Lectures, laboratory work covers:
 Systems biology: what it is, methods, issues and opportunities.
 Mathematical modeling. Types of models and their properties.
 Software for mathematical modeling and simulation in systems biology.
 System Identification: adaptation of mathematical models to experimental data.
 Validation and use of mathematical models. Troubleshooting and uncertainty analysis


Course literature:
Gunnar’s Crash Course in Systems Biology. Onlinelectures.


Examination: 

Tests 
2 ECTS



Grades are given as ’Fail’ or *Pass’.

Course language is English.
Department offering the course: IMT.
Director of Studies: Göran Salerud
Examiner: Gunnar Cedersund
